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内皮祖细胞可加速深静脉血栓的消融
发布日期:2017-08-15 11:22:58

Vascul Pharmacol. 2016 Aug;83:10-6. doi: 10.1016
Endothelial progenitor cells accelerate the resolution of deep vein thrombosis.
Li WD, Li XQ.

Abstract
      Deep vein thrombosis (DVT) causes high morbidity and mortality. Successful resolution of DVT-related thrombi is the key point in the treatment of DVT. Recently, endothelial progenitor cells (EPCs) which are multipotent progenitor cells mainly residing in human bone marrow have emerged as a promising therapeutic choice for DVT-related thrombus resolution. In this review, we discussed the mobilization and homing property of EPCs into the sites of thrombosis, mechanisms of EPCs in DVT-related thrombus resolution from the aspects of promoting endothelial regeneration, revascularization, vasoactive and angiogenic factor secretion, proteinase generation, thrombus propagation and recurrence prevention, and vein wall remodeling. In addition, we also provide suggestions on EPCs as a therapeutic choice for thrombus resolution.
      深静脉血栓是常见的血管类疾病,有较高的发病率和致死率,溶栓是DVT的关键治疗方法。内皮祖细胞EPCs是主要来源于人骨髓的多能干细胞,它可能为DVT提供新型的生物溶栓治疗方法。

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